Recent research on Boswellia serrata indicates 11-keto B-boswellic acid (KBA) may be the appropriate active biomarker to measure consumption of Boswellia extracts.

A human pharmacokinetic study found a single 333 mg dose of Wokvel, from Verdure Sciences, led to a maximum KBA plasma concentration of 2.7 micromolar. The concentration needed to cut in half the activity of 5-lipoxygenase, a primary mediator of the inflammatory process, was found to be at least 2.8 micromolar.

This study on CACO-2 cell cultures measured bioavailability through the GI tract and found moderate absorption of KBA, compared to the measurement of other marker compounds from Boswellia. For further information: www.vs-corp.com